AGE LESS™

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Astragaloside IV (AS-IV) primarily works by

activating the enzyme telomerase, which

in turn helps to prevent telomeres from

shortening and can even lead to their

elongation, thus supporting cellular health

and potentially delaying aging. It activates

telomerase by increasing the expression of

the TERT gene (which codes for

telomerase) and by influencing signaling

pathways like Src/MEK/ERK, ultimately

counteracting telomere attrition.

Telomeres are protective, repetitive DNA

caps at the ends of chromosomes, similar

to plastic tips on shoelaces, that prevent

genetic data from unraveling during cell

division. As cells divide, these caps

shorten, acting as a biological clock for

aging; critically short telomeres lead to cell

death or senescence.

Telomerase is a specialized

ribonucleoprotein polymerase enzyme

that maintains telomere length by adding

DNA (TTAGGG repeats) to the ends of

chromosomes. It acts as a reverse

transcriptase to counteract the natural

shortening of chromosomes during cell

division, allowing cells to bypass

senescence and continue dividing.

Astragaloside IV (AS-IV) is a natural,

bioactive saponin compound derived from

the Astragalus membranaceus plant. AS-IV

acts as a telomerase activator, which helps

prevent telomere shortening and extends

cellular lifespan. AS-IV works by activating

the Src/MEK/ERK signaling pathway, which

subsequently upregulates telomerase

reverse transcriptase (TERT) expression.

Standardized Astragaloside IV (AS-IV) is

critical, as the primary active compound in

Astragalus membranaceus, it ensures

consistent potency, quality, and

therapeutic efficacy. Standardization

guarantees that each dose contains a

specific amount of AS-IV, allowing for

reliable results, as research indicates AS-IV

has a dose-dependent effect.

Quality assurance: It prevents variability

that can occur between different plant

batches, ensuring the supplement actually

contains the active compound at an

effective concentration.

Standardizing AS-IV ensures that AGE

LESSTM is a “therapeutic agent” rather than

an inconsistent herbal extract.

AS4™

Just $97

Standardized Astragalus Extract (10% Astragaloside IV)

  • AS4™ Telomerase Support Formula

  • Standardized Astragalus Extract (10% Astragaloside IV)

  • 60 Capsules per Bottle

  • Designed to Support Healthy Cellular Aging